| Objective: to evaluate safety of PDT on cornea and iris. Materials and methods: PDT was performed in ten eyes of the colored rabbits with different treatment variables. Argon green laser (wavelength, 514nm) was irradiated at the dose of 45.9~183.4J/cm2 (diameter of laser spot, 5mm). Blood circulation in the iris was investigated using indocyanine green angiography (ICG) of iris at one day before PDT and one day, one week, and one month after PDT. Histological changes were examined 2 hours after PDT. Results: No abnormal change in the circulation of iris was found in the ten eyes by the ICG examination. Light microscopy showed no inflammation reaction and visible injury. Electron microscopy demonstrated vacuolation in the mitochondrion of the endothelial cells and some endothelial cells were broken at the dose of 183.4J/cm2. Conclusion: PDT can be used safely on the cornea with HMME using argon green laser.
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