Studies Of Influence Of Different Posterior Operations On Osteogenetic Factors In The Rat Posterior Longitudinal Ligament

Background:The reason of OPLL is still unclear, there are some reports that OPLL progressed after posterior decompression. The reason may be the growing mechanic stress on the posterior longitudinal ligament caused by the destruction of the posterior structure of cervical spine. Objective: We do several types of posterior decompression on the rats, thus increase the stress on the ligament, and during different time, determine the quantity of TGF— β1 and BMP. We try to discuss the initiating and developing mechanism of OPLL, and the influence of different operation on its happening and developing. Method: Determine the quantity of TGF - β1 by immunohistochemical method, quantify BMP-2 and BMP-7 by PCR. Result: BMP — 2, 7 increase significantly in the operative groups; TGF— β1 has no significant difference in operative groups compared with the contrasting group. Conclusion: We deduce that BMP—2 and BMP-7 play important role in the early stage of OPLL and give suggestions on operation of OPLL...