The Relationship Between Prostate Specific Antigen Indexes And Prostate Disease

Objective: Investigating the relationship between prostate-specific antigen indexes and prostate diseases. Methods: analyzing retrospectively the TPSA indexes and prostate volume indexes in 4924 health male, 1629 BPH patients and 383 patients who suffered prostate biopsy in changhai Hospital. Results: 1, serum TPSA and FPSA levels are directly correlated with age both in healthy men and BPH patients ,whereas F/TPSA ratio levels show inversely correlated with age in healthy men. And there is no correlation between F/TPSA ratio and age in BPH patients. 2. The volume of total prostate and that of the transitional zone increase with age. 3, there are no correlation between Gleason score or PIN with serum PSA. 4, PSAD≥0.15,PSAT≥0.35, F/T≤0.16 and PSAD≥0.33,PSAT≥0.70,F/T≤0.14 were recommended to do prostate biopsy or not. 5, make up a model which allow the use of serum PSA for detection of the prostate cancer in clinic. Conclusions: serum PSA indexes could help distinguish prostate cancer from BPH or healthy.