Studies On The Proarrhythmic Effects Of Haloperidol And Sulpiride: Underlying Mechanisms, Proarrhythmic Conditions And Methods For Prevention

AIM: To explore the initial cellular mechanism of arrhythmia induced by Haloperidol and provide references for safe medication in clinical. METHODS: By using standard intracellular microelectrode techniques were used to record: 1) Effects of Haloperidol on cellular action potentials (APA, V_max, APD₅₀ and APD₉₀ ) of rabbit cardiac Purkinje fibers and guinea pig cardiac papillary muscles when Haloperidol was...