The Study Of Differentially Expressed Genes Stimulated By Transforming Growth Factor β1 In Hepatic Stellate Cells

Liver fibrosis is a compensative reaction response to various hepatic injury. It is commonly characteristic of proliferation and deposition of fibrotic tissue in many types of chronic liver disease. As long as the liver injury occurs, it will result in the excessive accumulation of fibrotic tissue and further develop into liver fibrosis. There are many etiological agents of liver fibrosis, the most common of them are virus hepatitis, alcoholic hepatitis and non-alcoholic fatty liver. The progress of liver fibrosis is often delitescence, the ultimate outcomes are cirrhosis and liver failure, even hepatocellular carcinoma. So liver fibrosis has become one of the most severe problems of public health worldwide. To block up the liver fibrosis is an important target on prevention and treatment of cirrhosis.Liver fibrosis is an unbalance outcome of the synthesis, degradation and deposition of extracellular matrix (ECM) during ther esponse to hepatic injury. It is a dynamic process of complicate fibrigenesis involving in cells and molecules. The keys of the pathogenesis of liver fibrosis is activation of hepatic stellate cells (HSC) and transformation into fibroblast. Cytokine plays an important role in regulating the...