| Subarachnoid hemorrhage(SAH) is a commonly hemorrhagic cerebrovascular emergency,and its most deadly complication is cerebral vasospasm(CVS), which induces Hypoxie and ischemic brain damage, following a high morbidity and mortality. Despite intensive research efforts to cerebral vasospasm pursuant to SAH for more than Std years, no consistent and integrated theory system exists, and its true mechanism and secondary impairment remain unclear. It has still been elusive for effective preventative and therapeutic treaiments.Recent years some scholars considered that apoptosis (programmed cell death , PCD) after SAH may play an important role in the delayed neuronal death(DND). Objective Main hazards of Cerebral vasospasm (CVS) following subarachnoid hemorrhage (SAH) is that it can bring about ischemic and anoxic neurological dei-icits. With the profoundly clinical and laboratory research into CVS, it is not confined to objective signs such as diminution of cerebral vessels and decreasing of regional cerebral blood flow(rCBF) for clinical therapy,but trying to find a new angle of therapeutics to aim directly at secondary brain injury from CVS following SAH. To supply a new thought and basis for effective method to prevent and treat brain injury after CVS following subarachnoid hemorrhage (SAH). So, to develop the effective drug on stroke has been the important project for researchers in the neurovascular field. Tretrandrine(Tet) is a major active compontent in the root of Stephania tetandra S. Tet has been used for the treatment of various diseases,including hypertension, cardiac arrhythmia, angina and inflammation. Recently, it was reported that Tet had a protective effect on the brain ischemia/reperfusion model in rats and gerbils. A series of studies have revealed that Tet blocked Ca2+channel in cardiac cells, neuroblastoma cells, neurohypophysial nerve terminals, and mesenteric... |
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