A Serial Study On The Value Of UFCT In The Diagnosis Of CAD

Coronary artery disease(CAD) is one of the major course of mortality. In china, the morbidity of CAD was 137/100,000 in 1980s, and increased gradually in recent years. The prevention and treatment of CAD is always the important field of clinical research. The diagnosis of CAD mainly depended on ECG,myocardial enzyme examination and imaging modality including X-ray, nuclear medicine and ultrasound. The final diagnosis relied on coronary angiography. Conventional computed tomography including spiral CT is an important method in diagnosis of various diseases of brain and body, however, it has had limited value in diagnosis of cardiovascular disease, because of slow scanning speed secondary to motion artifact. By use of electron beam technique other than the mechanical motion of x-ray tube, UFCT had rapid acquisition and reduction of motion artifact. Adjunctive with ECG trigger. UFCT gained excellent temporal and reasonable spatial resolution. It is the landmark in the diagnosis of cardiovascular disease by CT. This article dealed with a serial study on the value of UFCT in the diagnosis of CAD.I Quantification Of Coronary Artery Calcification By Ultrafast Computed Tomography In ChineseTo investigate the relationship of coronary artery calcification (CAC) and angiographically significant coronary artery disease,ultrafast computed tomography to detect coronary calcification was performed on 218 patients undergoing coronary angiography for proved or suspected coronary artery disease. Total calcium score was calculated as the sum of lesion-specific scores, each calculated as the product of density ≥130 Hounstield Unit and area ≥ 1mm~2. Significant coronary artery stenosis was defined as greater than 50% narrowing of lumen. Among 135 patients in whom CAC was identified, 86% had significant coronary stenosis, and 82% of 142 patients with with significant coronary stenosis snowed CAC by UFCT. The total score of CAC in patients with significant coronary artery disease (CAD) is much higher than that in patients without CAD, which score is 229±363, 42±125, respectively (p<0.001). Furthermore, calcification score in subjects with coronary stenosis over 75% is higher than that in subjects with coronary stenosis ranged from 50~74%. The number of vessels with significant stenosis has positive relation with total calcification score, on the other hand, the more the vessels with CAC , the higher the probability of the patients with significant coronary stenosis. The overall sensitivity, specificity and accuracy of CAC for stenosis are 82%,75% and 79% respectively. In the younger age group the sensitivity was lower and the specificity was generally higher than mat...