Role Of GR And NF-κB In The Hepatic Injury And Its Mechanisms In Rats Subjected To Severely Traumatic Shock

The severely traumatic hemorrhagic shock is often complicated with multiple organ failures, of which liver plays an important role in its pathogenesis. Hepatocyte damage and hepatic dysfunction lead to changes of the body in response to stress inevitably following traumatic shock. Therefore, it is very important to study the pathophysiological mechanisms of hepatic dysfunction following traumatic shock. If the correct and effective measurements were made before hepatic dysfunction happens, it would be possible to protect the occurrence of hepatic dysfunction, even systemic secondary damage and severe complications to a greater extent.GC action is one of the most important stress response of the body. The combination of GC and GR could create widely biological effects such as anti-inflammation, anti-allergic reaction and anti-shock. GR is the key component for GC playing its roles. It has been discovered that severe trauma could lead to the changes of expression and efficacy of GR. HSP plays key roles in the protection of organic and cellular damage of the body. HSP influences the activity of GR as one of the most important molecular chaperone. NF-κB could induce the transcription and expression of multiple cytokines related to immunity and inflammation and other relative gene so as to cause tissue and organ damage following severe trauma. GR counteracts NF-κB in regulating the immunoreaction and inflammation. GR has immunosuppression and anti-inflammation effects by inhibiting the expression of genes related to immunity and inflammation induced by NF-κB. However, there have been less reports about the changes of GR, HSP and NF-κB in the liver as well as their relationship with secondary damage and anti-damage of liver following severely traumatic shock. Whether GR, HSP and NF-κB are involved in the pathogenesis of traumatic shock are not clear. The roles of GR, HSP and NF-κB in the occurrence of hepatic dysfunction following traumatic shock remain to be determined. In the experiment, we used the bilaterial femur fracture combined with hemorrhagic shock model to observe the...