Expression Of MRPS17 Protein In Human Dermal Papilla Cell And Its Significance

Dermal papilla (DP) is a mesenchyme-derived structure situated at the base of the hair follicle and plays an essential role in embryonic hair morphogenesis and maintenance of hair growth cycle. It is the dermal papilla which directs and dictates the embryonic generation of a hair follicle and it also retains this instructive ability throughout the life of the hair follicle. DP consists of a highly active group of cells named dermal papilla cells(DPCs).DPCs retain their embryonic functional abilities and are able to induce new hair fiber growth in mature, adult skin when implanted into previously deactivated hair follicles and in close association with hair follicle epidermal cells. In the established hair follicle the DPCs act in conjunction with epidermal cells via mechanisms similar to those in embryogenesis to permit hair follicle cycling through hair production and resting phases. The dysfunction of dermal papilla usually abolishes the initiation of subsequent hair cycle resulting result in follicle-associated illness. Therefore, the study on the control of hair follicle growth and cycle should take functional status of DPCs into consideration. At the same time, DPCs are almost unique in maintaining their embryogenic regenerative properties in adults making them potentially attractive for investigation with a view to gaining an insight on organ/limb regeneration and similar studies.Hair growth proceeds on a cyclical basis through a repeated cycle of active follicular growth and rest phases, orchestrated by the dermal papilla that produces the required proliferative or inhibitory stimuli for hair growth regulation. Some active proteins or cytokines have been found to be involved in the regulation of hair follicle growth. However, it is still unclear which one is the key regulatory factor in the regulation of hair cycle. It has been proved that cell under different growth conditions express different gene. Selectivity and ordering of gene expression are the intrinsic base of the alteration of cell growth. So the...