Anti-thrombotic And Anti-tumoral Effects Of Cinnamaldehyde In Vivo

Cinnamaldehyde(CA) is an active compound isolated from the stem bark of Cinnamomum cassia, a traditional Chinese medicinal herb, which has several biological activities such as peripheral vasodilatation[1], anti-platelet aggregation[2,3], anti-tumor[4-10], anti-bacterial[11,12], anti-fungal[13,14]and anti-mutagenic[15,16].It has been reported that in vitro experiments, CA inhibited the blood platelet aggregation induced by collagen, arachidonic acid (AA) and adenosine diphosphate (ADP) and the conversion of fibrinogen to fibrin induced by thrombin [2]. These previous results could not solve the problem about the role of CA on platelet aggregation and thrombosis in vivo. Until now, there is no any information about this. Several studies have indicated that CA has growth inhibitory effects on a number of human cancers. The mechanism underlying the anti-tumor activity was included cell apoptosis and cytotoxic effects in vitro [4-10]. Until now, there is no study on the immunomodulatory and anti-tumor activity of CA has been reported, and not any information about the role of CA both cytotoxic activity and apoptosis-inducing properties in vivo.