Study On The Effects And Mechanisms Of Icariin, Baicalin Emodin And On Alveolar Bone Resorption

Periodontal disease is a chronic infective disease of the periodontium caused by bacteria present in dental plaque. This condition induces alveolar bone resorption until teeth are lost. It has been widely acknowledged that there is hardly any effective method in the prevention and treatment of periodontal diseases or periodontal tissue defects especially alveolar bone resorption. Much effort has been made to develop drugs for prevention and treatment of bone resorption. Recent approaches include the development of small natural compounds extracted from natural plants , which retain the beneficial effects while minimizing the adverse side effects. Privious studies showed that some extraxts can directly or indirectly inhibit osteoclastogenesis and the function of mature osteoclast by blocking the release of the factors which stimulate bone resorption. Screening for active components that inhibit bone-resorbtion from these extracts may be a new way for finding method in the prevention and treatment of for periodontitis. Baicalin is a flavonoid purified from the medicinal plant scutellaria baicalensis georgi. Emodin was extracted from the root of rheum.palmatum. Both of these plants have been used in herbal formulas to treat inflammatory diseases for thousands of years in traditional Chinese medicine. It has been reported that...