A Study On Atrial Fibrillation Mechanism And Catheter Ablation In Four-dimensional Mapping

Background: Atrial fibrillation (AF), the most commonly arrhythmia in clinicalpractice, is associated with substantial morbidity and mortality. For many years, drug therapy has been the main treatment for the patients of AF. Unfortunately, many patients failed to respond to the drug therapy. It has been confirmed that spontaneous electricaldriver from pulmonary veins plays an important role in AF electrophysiological mechanisms. Many therapeutical strategies and techniques aimed at pulmonary vein isolation have been developed and modified, and rewarded with improved outcomes. But whether all patients need to isolate all the 4 pulmonary veins routinely, how to detect and ablate the non-PV foci are significantly in simplifying the ablation procedure and improving success rates. In present study, we used the noncontact mapping system(Ensite 3000) to map the isopotential activation during AF, analyzed the spatiotemproal organization of the wavefronts and the activation sequence, and performed individualized ablation strategies according to each patient's characteristics of the electrophysiologic process. Our research assessed the safety and feasibility of this approach and also analyzed the factors associated with its effects.Objectives:We want to perform individualized ablation strategies according to each patient's characteristics of the electrophysiologic pattern with non-contact mapping the isopotential activation sequence during AF. We will assess the safety and feasibility of this approach and also analyze the factors associated with its effects.Methods:The study included 52 patients, paroxysmal AF 39 cases, persistent AF 11 cases...