Clinical And Experimental Research On Role Of Alloreactive Natural Killer Cell In MHC Mismatched Hematopoietic Stem Cell Transplantation

Objective1 To investigate the expression of four type natural killer (NK) cells inhibitory receptors (CD158a, CD158b, NKB1 and NKG2A) on peripheral blood NK cells and T lymphocytes in patients before and after allogeneic hematopoietic stem cell transplantation and the relationship with acute graft-versus-host disease (aGVHD) .2 To explore the role of graft-versus-host (GVH) direction KIR ligand incompatibility on outcome following MHC mismatched hematopoietic stem cell transplantation.3 To study the effect of alloreactive NK cells on eliminating recipient-type T cell and granuiocyte, reconstituting of hematopoiesis and engraftment in murine MHC mismatched hematopoietic stem cell transplantation.4 To examine the effect of alloreactive NK cell on preventing GVHD in graft containing replete T lymphocyte.Methods1 Flow cytometry analyzes the expression of four type NK cells...