MRNA Expression Alterations Of Potassium Channel Subtypes In Rat Brain With Cerebral Ischemia And Cholinergic Impairment

In the central nervous system, electrophysiological activity is the basis of neural functions. There are many kinds of ion channels on the membrane of neurons, whose activities are crucial for controlling the membrane potential of neurons and regulating the excitability of CNS. K+ channels, which play the most important role in electrophysiological activities, have the largest superfamilies and the most complicated classification by now. Potassium channels are also closely related to kinds of neural physiological and pathological conditions such as learning, memory and brain injury. With the development of molecular biological techniques, various potassium channel subtypes were discovered. Many studies on the different functions and tissue distributions of potassium channel subtypes have been reported. However, there was little research on the possible alterations of some specific potassium channel subtypes and their corresponding pathological meanings in the process of related diseases. Here we studied the mRNA expression alterations of potassium channel subtypes in the process of brain...