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Study On Tissue Engineering Artificial Cartilage

Posted on:2006-06-06Degree:DoctorType:Dissertation
Country:ChinaCandidate:J H YanFull Text:PDF
GTID:1104360185473779Subject:Biomedical engineering
Abstract/Summary:PDF Full Text Request
Articular cartilage defects are a major problem in orthopedic Surgery. Because the cartilage tissue itself lacks a blood supply to support repair and remodeling, once damaged, the articular cartilage has little capacity for spontaneous healing. Most of the current therapies to repair damaged cartilage have focused on the abrasion arthroplasty, excission, and the use of perichondreal or periosteal autografts. But the results have some limitations, and all fail to produce long-lasting repair tissue. To solve this limitation, recently, a tissue engineering technique has proved to be one of the most promising approaches for cartilage repair.Tissue engineering of articular cartilage involves the isolation of articular chondrocytes or their precursor cells that may be expanded in vitro and then seeded into a biocompatible matrix, or scaffold, for cultivation and subsequent implantation into the joint.A three-dimensional biodegradable porous scaffold plays a vital role in a tissue engineering approach. The advantages of incorporating scaffold into this approach are that the scaffold matrix can provide the initial structural support and retain cells in the defective area and can act as a delivery system for nutrients and metabolites.One of the considerable characteristics in the cartilage tissue is that a small number of chondrocytes are embedded in the rich ECM. Therefore, cell-matrix interactions play a crucial role in the development and regeneration of the cartilage tissue. So, scaffold plays an important role as the extracellular matrix (ECM) during engineered tissue development.To successfully achieve cartilage tissue regeneration, an ideal cell-carrier substance (matrix) should be the one which most closely mimics the naturally occurring environment in the articular cartilage matrix.Porous collagen(Col) matrices with defined physical, Chemical, and biological characteristics have a great potential in tissue engineering.In the current study, hyaluronic acid (HA), chitosan (Chi) and chondroitin sulfate...
Keywords/Search Tags:Tissue Engineering, Collagen, Hyaluronic acid, Chitosan, Chondroitin sulfate, The back of athymic nude mouse, Tissue engineering artifical cartilage
PDF Full Text Request
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