Localization Of ANP-synthesizing Cells And Effect Of ANP In The Stomach On The Secretion Of 5-HT In Rat Gastric Mucosa

Since antrial natriuretic peptide (ANP) was isolated from atrium by de Bold et al in 1981, brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis (DNP), micrurus natriuretic peptide (MNP), and ventricular natriuretic peptide (VNP) were found in succession. They distribute in all over the body not only in the heart. ANP regulates a variety of physiological function, including natriuresis, diuresis and vasodilation.Three types of natriuretic peptide receptor for ANP, BNP and CNP have been identified, for example, natriuretic peptide receptor type A (NPR-A), type B (NPR-B) and type C (NPR-C). ANP bind NPR-A of target cell membrane has induced the synthesis of cGMP through the activation of membrane-bound guanylate cyclase or particulate guanylate cyclase. cGMP can activites cGMP-dependent protein kinase,accordingly mediates the biological functions through the catalysis these residue or seridue residue of relation protein or relation enzymes phosphorylated. NPR-A preferentially bind ANP and BNP, but has a low affinity for CNR Although ANP synthesized synthesized primarily in the heart as a cardiac hormone, in the fact that ANP and its receptor were expressed in numerous extracardiac tissues,e.g, lung, thymus, gastrointestinal tract, suggested a possible role as a regional regulator acting as an autocrine and/or paracrine regulatory peptide.Our previous study indicated that NPR existed in different regions of gastric wall and its density was the most in gastric antrum in rat, and NPR...