Monitoring And Prevention Of Fat Intravasation During Early Stage Treatment Of Femoral Fractures

Objective: ①To study intramedullary pressure(IMP) change during open intramedully nailing(OIMN) of fresh femoral fractures and the factors leading to the change. ②To study fat intravasation and its relation with IMP during OIMN of fresh femoral fractures. ③To evaluate the effect of medullary cavity clearing and vacuum sucking on fat intravasation during OIMN of fresh femoral fractures. ④To estimate the value of transcranial Doppler ultrosonography(TCD) in monitoring fat intravasation during OIMN of fresh femoral fractures. ⑤To observe the dynamic change of pathological detection for free fat in blood ,TCD microembolus monitoring and cranial MRI in early stage of fat embolism syndrome(FES). ⑥To estimate the value of TCD in the prediction and early diagnosis of FES.Methods: The first part: ①50 patients with femoral fractures were submitted to OIMN in early stage after injury. ②Before operation, a hollow probe was screwed into the medullary cavity and linked with a pressure monitor to record the pressure change during the OIMN process. ③5ml blood was taken from femoral vein of the affected limb individually before operation and just after fixation of intramedullary nail. The blood clots were made into frozen sections and stained by oil red-0 to find...