The Anticancer Effect Of Nolarexed Dihyrochloride PLGA Nanoparticales On Cell Line MFC In Vivo And In Vitro

Background and ObjectiveForty Era in Twenty Century, the tumor chemical therapy emerged, from then on, it has developmented into one of the main three therapies to malignant tumor. The therapeutic effects and toxicities of antitumor drugs have intimate correlation to the proliferation kinetics of malignant tumor cells. The antitumor drugs can be devided into two kinds of CCNSA and CCSA according to the sensitive differences to each cell generation cycles. The former mainly contributes to the cells of reproductive cycle, including G₀-stage cells, and this kind of drugs consists of aldyl agents and antineoplastic antibiotics, whose therapeutic effects are dose-dependent. The latter mainly contributes to cells of multiplication period, being insensitive to the G₀-stage cells, and is administrative opportunity-dependent. Controlling the relationship of drugs and cell cycle, we can be instructed clinically to use exactly chemotherapeutics, cut down the toxic and side effect and enduce the best therapeutic efficacy.The nanometer technolgy is a new skill that is to study the structural feature and the interaction of the atom and molecule in the l-100nm size. The nanometer technolgy has achieved dramastic development since 1990s, and it gives great changes in many fields.It is obvious that the penetration and affection of the nanometer technology to biomedical engineering. The study of exploitation and analysis of the compatible of biologic and matter, the optimization of detection tecnolgy, and gene therapy...