An Experimental Study Of The Neuroprotective Effects Of NGF And GM1 On Injured Neurons

Nerve growth factor (NGF) initially interested neurobiologists because of its effects in the developing nervous system of the survival, differentiation and maturation. It is now clear that NGF functions throughout the life of the animal with a wide repertoire of actions. In the course of the last years, several lines of evidence converged to indicate that NGF participates in structural and functional plasticity of the dorsal root ganglia and spinal cord. NGF may induct the intracellular events, such as mitochondrial transport or accumulate at regions of focal NGF stimulation, and intracellular Ca²⁺ homeostasis. The expression of NGF is increased after injury of the nervous system. It is necessary in order to help preserve architecture and restore function of the nervous system. NGF has protective effects on neuronal injuries. The contents of monosiagangliosides (GM1) have obviously alterations during the development of the nervous system. There have biological synthesis changes in the course of inductive differentiation depends on the results of in vivo and in vitro experiments. The contents of GM1 increased in nuclear membrane during the differentiation of neurons. The proliferation and maturation effects of GM1 on the cell growth may modulate through peptide growth factors. Sprouting from DRG is induced by NGF and GM1. The neuroprotective mechanisms of NGF...