Chemoprevention To Colorectal Cancer By Tea Polyphenol Epigallocatechin Gallate And Its Underlying Molecular Mechanisms

Background:The incidence of colorectal cancer has steadily been increasing worldwide, and the long-term survival has not improved in the past 30 years. The reason for this changing epidemiology is not clear but individual's behavior and dietary habits have been implicated. Thus, a more westernized diet may be linked to the increased incidence of colorectal cancer. Although significant progress is being made in cancer-therapy research, it is neither as rapid nor as efficient as it might be. For this reason, many scientists, all over the world, have focused their attention on chemoprevention of colorectal cancer and several chemoprevention strategies have been proposed and gained attention. Such researches and insights into carcinogenesis will contribute significantly and fundamentally to our understanding of colorectal cancer and its molecular and genetic progression. Moreover, the effort will help to identify and validate important targets for intervention and prevention. Recent studies have shown that high consumption of red and processed meats is associated with an increased risk of colorectal cancer. 2-Amino-3-methylimidazo [4,5-f] quinoline (IQ), a mutagenic and carcinogenic heterocyclic amine produced during cooking of meat and fish, as well as many chemicals in foods, has been blamed for the induction of...