The Correlative Study Of The Histopathological Grading Together With Tumor Invasion In Brain Gliomas And Functional Magnetic Resonance Imaging

Brain gliomas have the highest incidence in intracranial malignant tumors. The degree of malignance and invasion of gliomas are related closely to the clinical diagnosis and treatment, together with the evaluation of recurrence and prognosis. By conventional CT and MRI, determination of the definitive diagnosis and the degree of malignance are mainly according to morphology such as uniformity of tumor, cysts, hemorrhage and necrosis inside, the borders, mass effect, the degree of peritumoral edema., the feature and degree of enhancement et al. Recently new technologies such as functional CT and MRI, SPECT, PET were applied to brain gliomas, which improve the study of biological characteristic of gliomas from perfusion , function and molecular level., for example: angiogenesis, peritumoral invasion and metabolism. Function magnetic resonance imaging generally including perfusion weighted imaging, diffusion weighted imaging, MR spectroscopy, and cerebral cortex functional imaging. The former three technologies were applied to this problem to access the angiogenesis, peritumoral invasion, metabolism of gliomas differently, at the same time investigating the relativity to Vascular endothelial growth factor (VEGF) , matrix...