Inducible Effect Of Interleukin-6 And Inhibitory Effect Of Tetramethylpyrazine On The Expression Of Tissue Factor In Vascular Endothelial Cells

Considerable evidences have been accumulated to indicate that there is an inflammation - coagulation network in vivo. Proinflammatory cytokines [such as tumor necrosis factor (TNFa), interleukin-6 etc.] not only induce inflammatory process, but also promote coagulation activation. Inflammation and coagulation belong to the component parts of defense response. Besides coagulation activation, the serine proteases in blood clotting process induce a series of cellular reactions particularly their involvement inflammation through specific receptors. Among all of these process, tissue factor(TF) expressed on activated vascular endothelial cells(VEC) may present as a major link between inflammation and thrombosis.Vascular endothelial cells participate in the regulation of physiological hemostasis through controlling of the procoagulant activity as well as anticoagulant activity on the cell surface. TF is of major biological significance for the procoagulant properties of endothelial cells and monocytes. It functions as a transmembranous receptor that specifically binds coagulation factor VII or VIIa and accelerates the convertion of FVII into FVIIa. The expression of TF in vivo has been associated with coagulopathy and thrombosis in damaged vessels in a number of diseases such as septic shock, atheroma and disseminated intravascular coagulation(DIC).Interleukin-6 (IL-6), as a major proinflammatory cytokine, has extensive biological activities and plays a central role in coordinating the acute-phase response to trauma, injury, and infection in vivo. A variety of infectious diseases and cardiovascular accidents cause increase in plasma IL-6 level, and the increased IL-6 level is positively correlated with mortality. IL-6 is of same importance as TNFa in diseases such as atherosclerosis and acute coronary syndrome. The biological activity of IL-6 may be mediated by binding of IL-6 to IL-6 receptor (IL-6R). Because there is no IL-6R on the membrane of VEC, we have no seen the published articles about the relation between IL-6 and TF expression in VEC. Recent studies demonstrated that IL-6 can bind soluble IL-6...