The Study On The Association Of Chemokines And Their Receptors Genes With Cerebral Infarction

The cerebral vascular disease (CVD) is a main deadly and disabled common disease. In our coutry, the incidence of CVD is still head the list. The CVD threatens human health seriously, also brings heavy burden to the family and the society. Therefore, it is important for the medical workers to study the etiology, mechanism, prevention and therapeutics of CVD, especially to the cerebral infarction.To decrease the ischemic brain lesion and improve the quality of cerebral infarction patients' life, it is very important for the doctors to reveal the mechanism of cerebral ischemic injury. The mechanism of neuronal injury in the cerebral ischemia is complicated. More and more study results demonstrate that the cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators. Under the chemotaxis of some chemotactic mediators (the chemokines), many leukocytes present in the ischemic brain tissue, and the monocytes/macrophages are the predominant cells present after early polymorphonuclear cell infiltrating into the ischemic lesions. And then these leukocytes produce such chemical damaging mediators as the cytokines, the free-redical to exacerbate the brain insult. The issue of cerebral ischemia is an inflammatory disease has been widely received.