Digging The Proteins Interacted With Apoptosis Associated Proteins In Liver By Large Scale

Apoptosis is highly controlled for cell death. It has foundational function to maintain tissue homeostasis. Recently large numbers of studies suggest, Apoptosis is a physiological process,and it can be activated by signals in vivo and in vitro. Deregulation of this process contributes to a number of human diseases that are caused either by an increase in cell death, or enhanced cell survival. There are mainly two ways to activate apoptosis, one way involves the activation of a family of proteolytic enzymes known as caspases through in vitro signals. The other pathway to apoptosis is through caspase activation triggered by cytochrome c following its release from mitochondria into the cytoplasm. The activated caspases make the important proteins in cells degraded, and this induces apoptosis.Liver is an important organ in human body. Recently studies show, apoptosis has a important role in liver diseases. In hepatocirrhosis, there is apoptosis ubiquitously occured in the liver cells, bile duct cells and monocyte. In the process of hepatocellular carcinoma development, not only abnormally hyperplasia of the cancer cells, but also the decrease of...