The Experimental Study Of Gene Therapy For Hepartocellular Carcinoma Through RNAi Targeting HTERT Gene

Primary hepartocellular carcinoma (HCC) is one of the commonest malignant tumors in our country. 42.5% of the the newly occurred cases each year over the world is in China. HCC is the second tumorigenic pathogen and the death rate increased by 41.7% in the past twenty years. Surgical operation is the well-known and best therapy for HCC. However, HCC is of easy early metastasis and late apparent symptom so that to miss the optimal operation period when 70% patients were diagnosed. Therefore, it is very important to look for new therapy strategy in both theoretical and practical significance.The current researches have shown that the occurrence, development and prognosis of HCC are closely related to the abnormal expression of telomerase. Telomerase is a ribosomal nucleoproteinease, composing of nucleic acid and protein, which is a reverse transcript DNA polymerase depending on self-RNA. Telomerase plays key roles in maintaining telomere length, acquiring cell immortality and tumor proliferation. Telomerase is composed of telomerase RNA (hTR), telomerase related...