Intracortical Injection Of Ferrous Chloride Induced Posttraumatic Epilepsy Model In Rat And The Relevant Mechanisms Of Posttraumatic Epileptogenesis

BackgroundThe epilepsy is a common harmful nervous system diseases.It has been reported there are at least 6,000,000 persons involved in epilepsy and the occurrence rate of epilepsy was about 3.5‰~4.8‰ in China.Traumatic brain injury (TBI) is also a major risk factor for development of epilepsy.Seizures may occur immediately after the injury, but there may be a delay of months or even years before seizures commence.In general, the incidence of posttraumatic epilepsy(PTE) varies with the time period after injury and population age range under study, as well as the spectrum of severity of the inciting injuries, and has been reported to be anywhere from 4 to 53%. As high as 86% of patients with one seizure after TBI will have a second in the next 2 years. Intracerebral hematoma (especially subdural hematoma)is a significant risk factor for the development of seizures in the first week and >1 week after injury . Prior attempts to prevent posttraumatic epileptogenesis used various anticonvulsants, usually given many hours after injury. Generally these studies showed these agents suppressed seizures in the first week after trauma, but had no effect on the incidence of late posttraumatic seizures. There is a pressing need to find alternative strategies...