Experimental Study Of Protection On The Kidney From Rejection By The Liver In Combined Liver And Kidney Transplantation And Its Mechanisms

Objective:To observe the protection on the kidney from rejection by the liver in combined liver and kidney transplantation, and explore its probable mechanisms. Materials and methods:I. The experimental model establishment of rat kidney transplantation SD rats were used both as kidney donors and as recipients. Resected donor organs were left kidney, left kidney vessels, arteria abdominalis, vena cava caudalis, left ureter and vesica urinaria. The vena cava caudalis was passed through the lumen of the cuff, and its end was then everted over the cuff and secured in position using a circumferential silk suture. Arterial anastomosis: the whole arteria abdominalis below the renal bifurcation was freed and transected at the midpoint. Continuous sutures were placed in arteria abdominalises of donor and recipient by using extradural catheter as inner supporting tube. When suturing the upper orifice, the extradural catheter ripped into artery through the lower ostium of donor arteria abdominalise. And when suturing the lower orifice, the extradural catheter ripped into artery through arteria mesenterica cranialis. Then arteria mesenterica cranialis was ligated.