Study On Survival And Apoptosis Of Supraoptic AVP Neurons After Hypophysectomy Or Hypophyseal Compression In Rats

Hypothalamo-neurohypophyseal tract is formed by the nerves from the magnocellular neurons in hypothalamic suparoptic and paraventricular nucleus, which ends the neurohypophysis. It's main function is to synthesis, transfere and release of AVP and OT from magnocellular neurons. There are many functions of AVP and OT released from hypothalamus in the body, AVP can regulate the reabsorption of water in renal distal convoluted tubule and the metabolism of water and electrolytes. Injury of hypothalamus, pituitary stalk and neurohypophysis by trauma, tumor and operation in neurosurgery will make AVP insufficent of synthesis or releasing, which can cause central diabetes insipidus (CDI). Others found that CDI appeared after hypophysectomy or injury of pituitary stalk. The degeneration of magnocellular neurons also will occurs in hypothalamus nucleus after HNS' interruption. There is tight relationship between CDI and the degeneration of magnocellular neurons in hypothalamic nucleus. It is useful to prophylaxis and treat the CDI when we understand the mechanism of magnocellular neurons' degeneration and survival after axonal injury. Nowadays traditional hypophysectomy (including neurohypophysectomy), compression or...