Multiple Damage Mechanisms Of Nephropathy In Rats Induced By Respiratory Syncytial Virus

ObjectiveTo construct respiratory syncytial virus (RSV) nephropathy rat model, and to study the multiple mechanisms of nephropathy induced by RSV, including the effects of disequilibrium of elastase (ELA)—a1-antitrypsin (a1-AT), the damage of RSV itself and N-deacetylase/N-sulfotransferase 1 (NDST1) on the kidney, thus providing a new clue for exploring the pathogenesis of minimal change nephrotic syndrome (MCNS) and providing theoretical foundation for therapy.Methods1. Rats were inoculated with 6×10², 10⁴, and 10⁶PFU RSV, and sacrificed on days 4, 8, 14 and 28 postinoculation (RSV₄, RSV₈, RSV₁₄, RSV₂₈). The renal histology was observed by light microscopy and electron microscopy; the urinary protein and glycosaminoglycans(GAG), serum albumin, cholesterol, urea nitrogen and creatinine were measured; RSV RNA...