The Effect Of Celecoxib On Cerebral Vasospasm In Rabbit Model Of Subarachnoid Hemorrhage

Part One:The Establishment of the Vasospasm Model after Subarachnoid Hemrrhage in Rabbit and The Experimental Study of the Permeability of Blood-Brain Barrier after Subarachnoid Hemrrhage Objective:To establish the Model of Vasospasm after Subarachnoid Hemrrhage in Rabbit.To examined the relationships between apoptosis and the disruption of blood-brain aarrier (BBB), brain edema in the SAH model. Methods:Thirty-six New Zealand White rabbits were randomized to six experimental groups.The SAH model was produced in anesthetized rabbits by injecting 1.5cc autologous fresh arterial blood into the cisterna magna.Control animals underwent sham operations.The animal were killed at 72 hours after SAH.In operation group-1 and control group-1, their bodies perfused and fixed, and their basilar arteries processed for morphometric analysis ,...