The Pathogenesis Of Infantile Hemangioma And An Experimental Study On The Therapy For Infancy Hemangiomas With Recombinant Interferon-γ

Background/Purpose: Infantile hemangioma is one of the most common benign tumors in children. A important pathological character of hemangioma is that it could appear the excess proliferation of endothelial cells . It could grow rapidly during life early but regresses spontaneously beyond 1 age. The pathogenesis of hemangioma is still unclear. Recently, there were researches confirmed that endothelial progenitor cells(EPCs) were existed in hemangioma and EPCs contributed to the early growth of hemangioma. However, the role of EPCs in the growth of hemangioma and the way of EPCs proliferating remained unknown. The aim of this study was to investigate the expression of EPCs in hemangioma and to discuss the relations of the EPCs and pathogenesis in hemangioma.Methods: CD133mRNA expressed in 13 proliferating hemangioma specimens, 15 involuting hemangioma specimens, 11 vascular malformation specimens, 12 normal skin (foreskin)tissues and 10 placental chorion specimens were detected by reverse transcription-polymerase chain reaction(RT-PCR). Simultaneously, hemangiomas, vascular malformations and normal skin tissues were subjected to assay with immunohistochemistry for CD133, CD31, TERT and Ki-67.The process of EPCs proliferation was...