The Role And Mechanism Of NF-κB In TRAIL-induced Apoptotsis Signal Conduction Pathway In Glioma Cells

Objective Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a new member of the tumor necrosis factor superfamily. TRAIL can bind the necrotic receptor on the surface of the target cell membrane and induce tumor apoptosis selectively while having no significant toxic effect on the normal cell. It is a new kind of broad-spectrum antineoplastic agent, having extremely latent capacity. The selectively killing effect of TRAIL on tumor cell brings about a new moment for oncotherapy, which aimed at TRAIL becomes a hot spot in the field of tumor research for the past few years. So far, the application of TRAIL to oncotherapy has made great progresses all of the world, but it needs to be studied further that the concrete mechanisms and its regulative factors of the TRAIL induced tumor cell apoptosis. Now, the research about TRAIL and glioma is just at the beginning, many basic questions needs to be clarified. Here, on the basis of forthcoming theories and experiments, we have approached further questions below: (1)The activation effect and mechanisms of TRAIL on nuclear factor-kappa B in glioma cells; (2)The influence of NF-κB inhibitor on TRAIL induced apoptosis in glioma cells.(3)The influence of TRAIL and NF-kB inhibitor on the expression of FLIP mRNA and the activity of...