P63,P53 Expression In Ovarian Carcinoma And The Variable At MRNA Leve After Apoptosis Induced By Caboplatin

Objectives:(1)To investigate the possible relationship between expression of P63, p53 and clinical charactersof ovarian carcinoma. (2) To study the variable at mRNA leve in apoptosis induced by caboplatin, and the possibility of P63 involving chemoresistanceof caboplatin and the primary relationship between P53and P63.Methods: (1) p63, p53 expression were studied in 9 cases of normal ovarians, 40casesof serous cystadenoma, 18cases of ovarian bordline tumors, 48cases of serous cystadenocarcinoma by means of immunohistochemistry. (2) The apopotosis was induced by caboplatin, the protein and mRNA of P53, p63 were investigated by meanses of immunohistochemistry, flow cytometry and real-time fluorescence quantitative reverse transcription-PCR. Results: (1) No p53, P63protein was expressed in normal ovaries and.no expression in serous cystadenoma. (2) P53, P63protein was found in nuclear . P53, p63 presented in16.7%, 11.11%of cases of...