The Effect Of Allogenic Hematopoietic Stem Cell Transplantation On Tumor Recurrence And Metastasis Of Hepatocellular Carcinoma After Radical Hepatectomy

Hepatocellular carcinoma (HCC), the main type of primary liver cancer, is one of the most common and aggressive malignancies worldwide and it is the second most common cause of cancer death in China. Hepatectomy remains the standard treatment for HCC, but the overall survival rate is far from satisfaction for the recurrence and metastasis of tumor after operation. Recurrence and metastasis are quite common , being as high as 40～50% in five years after curative resection even for small liver cancers less than 5 cm in diameter. Recurrence and metastasis have become the most prominent obstacles to further improvement of clinical treatment efficacy and manyefforts have been made to find a more efficient treatment to inhibit and prevent them. Along with the development of molecular biology ,tumor immunology and genetic engineering ,biotherapy includeing immunotherapy, is becoming a very hopeful strategy to eliminate the residuary tumor cells of host origin.