The Combination Of Apoptosis Induction And Active Immunotherapy With The Plasmid Of Vesicular Stomatitis Viruses M Protein Based Gene Therpy

Aberrant regulation of cell growth has been viewed as the major underlying mechanism for tumor formation; however, it is becoming increasingly clear that cellular changes that lead to inhibition of apoptosis play an essential role in tumor development. Apoptosis induction that are triggered by anticancer therapies is thus an important area that may provide insights into facilitate the development of novel anticancer therapies. Because of its potent ability to induce apoptosis, vesicular stomatitis virus (VSV) is an attractive candidate as an oncolytic virus for tumor therapy. Although VSV has many advantages in cancer therapy, the live virus is confronted with the problem of bio-safety and effectiveness. Therefore, it's very necessary to develop new strategy for using the VSV as an antitumor...