The Study Of The Effect Of AP-1 On Chemokine Expression And Curcumin Inhibition In Infection Associated Preterm Delivery

background Preterm delivery (PTD) is one of the most important reason for the perinatal sickness and death. PTD is a common complication of pregnancy from many reasons which resulted in uterus contraction and dilatation of cervix and at last the pregnancy terminated earlier than normal. But, the mechanisms explaining how labor onset and progresses are no clear. Recently, the researchers reported that infection is a common cause of PTD and there was a relationship between PTD associated with infection occurs and an inflammatory response mediated with inflammatory cytokines. Activating transcription factor AP-1 may bind to a corresponding inflammatory cytokines genes site and regulate expression of cytokines. AP-1 may play a vital role in parturiens with PTD associated with infection. Objective 1. To study the effect of AP-1 and AP-1 regulate MCP-1(monocyte chemoattractant protein-1)gene expression with LPS , LPS+CUR treatment cells. 2. To determine the role of AP-1 in the animal model of infection associated with preterm...