The Construction Of Nucleic Vaccine Encoding HCV Core Protein And Induction Of Immune Response In Mice

Hepatitis C virus(HCV)has been shown to be the major cause of parenterally acquired viral non-A, non-B hepatitis. In most cases, the virus causes a persistent infection, and previous studies clearly indicate an association between chronic infection with HCV and the development of chronic liver diseases, cirrhosis, and hepatocellular carcinoma. Approximately 500 million people is chronically infected in the world. Unfortunately, up to now vaccines prepared with traditional approach often fail to work owing the variability of HCV. Nucleic vaccine is a new kind of vaccine, in which genetic material be introduced into body by either direct or indirect means. It has several potential advantages over other vaccines. Several models of DNA-based immunization against...