Experimental Study Of The Mechanism Of Lung Injury And Protection During Cardiopulmonary Bypass

Lung injury during cardiopulmonary bypass (CPB) may result in severe complication after open heart surgery. It relates to the mortality of the patients undergoing CPB. However, the mechanism of the injury and how to protect it effectively remain to be important clinical problems. We used a rabbit model of CPB to study the possible mechanism of lung injury and to assess the effects of lung protective methods during CPB. The study includes five parts:Part I Experimental study of the ischemia-reperfusion injury oflung during CPBIn present study, adult white rabbits (n=20) were used. They were divided into two groups: CPB and sham operation group(n=10),four of which were used to test the vascular permeability. In CPB group, CPB were set up after connecting tubes and priming. When the temperature was 28℃-32℃, aorta and pulmonary artery were crossclamped. The heart arrested with cold St. Thomas II solution (4℃ ).After 60 min, aorta and pulmonary blood flow were reestablished. Part CPB continued for 60 min,...