Interaction Between Free Radicals And Their Scavengers, And Regulation On Activation And Expression Of Genes In Cancerous Cell Cycle

Recent years, relationship between cancer and free radical biology has been attached importance by medical scientist. The main reasons are that differences of the membrane structure between normal and cancer cells, lower background levels of free radical substances, gene of resistance to drug and resistance to apptosis, cellular activation needed to active oxygen has been discovered, and research on high efficient free radical scavengers has been took as important topic. The hypothesis of "multi-antioxidants chains" posed by our research group in 1990 consisted of distinct form of antioxidant that to acqure high efficient antioxidation, should be one with different water-solvable or fat-solvable, different molecular weight different staying and action site, different electric charge, and that could play an important role on inhibiting active oxygen injury and scavenging free radicals ( O, OH, H2O2, ROO ) those had stimulation on pre-cancerous lesions to develop cancer in cells and tissues by synegestic action and complement each other, because that free radical reaction is highly related to lipid peroxidation; The action of single anti-oxidant used is finite and has easilly overload in vivo.Recent research results show that there are many differences between cancer cell and normal cell in structure and function: (1) the cancer cell in composition of polyunsaturated fatty acid is different and unsaturated double bonds of that is less than that of normal cellular membrane. (2) the Mn-SOD and catalase, which are antioxidative enzymes, is absent. (3) the active oxygen in high level is important in initiation of early stage of tumor occurrence. (4) the free radicals background level in cancer are low. (5) the...