A Study Of Cardiac Histamine H₃ Receptors On Its Finding, Function, Location And Possible Signalline Transduction System

The recognition of histamine as an autacoid in regulating the functions of many organs in human body started at the beginning of this century. Since then, research interest in the receptors that mediated the pharmacological actions of this biogenic amine has waxed and reached a peak when a new subtype of histamine receptor has been announced. In 1983 a paper from the research group of Schwartz, for the first time, showed that histamine mediated inhibition of its own release from slices of cerebral cortex through a new subtype of histamine receptor-H₃-receptor. Subsequently, the most potent and selective H₃-receptor agonist and antagonist were discribed by the same author in 1987, which further confirmed the existance of H₃-receptors. Now, an research interest in H₃receptor research is on the increase, which includes studies on its distribution, function, location and the intracellular signaling processes involved. It has substantially been show...