Jab1 Obstructed DNA Damage Checkpoint And DNA Repair By Inducing 9-1-1 Degradation

DNA damage is a common event in the life of a cell. Various environmental factors continually damage the genome of cells. These factors include endogenous and exogenous sources, such as ultraviolet light, ionizing radiation (IR) from the Sun's radiation, and oxidative stress derived from oxidative metabolism. In the long term of evolvement, organisms have developed mechanisms that maintain genomic integrity, which are highly conserved DNA-repair and DNA damage checkpoint pathways.DNA damage checkpoints are biochemical pathways that delay or arrest cell cycle progression in response to DNA damage. During DNA damage, DNA repair and DNA damage checkpoint were activated. Such checkpoint mechanisms make cells enter cell cycle arrest, and allow the cell time to repair the DNA damage before cell cycle progression is resumed, or, if the damage is too extensive, they trigger apoptosis or cellular senescence. Defects in cell-cycle checkpoints or DNA repair activity bring about the accumulation of genetic mutations, and then the accumulation of genetic mutations is an important cause of tumorigenesis.