| Studies have indicated that reperfusion may trigger a series of injury responses, and cause the corresponding organs lethality damage. Pulmonary reperfusion injury could occur after lung transplantation, extracorporeal circulation surgery, pulmonary artery thromboendarterectomy, pulmonary embolism thrombolysis and so on, but few therapies have been demonstrated for preventing such injury. The mechanism of lung reperfusion injury is still not clearly elucidated, which might possibly be involved with many kinds of factors such as the inflammation medium, the oxygen free radicals, the alveolar epithelium and the lung blood vessel endothelium damage. At present, some problems are still existed and waiting for further studies and solutions.In recent years, people are unceasingly exploring and seeking interventional measures in order to reduce reperfusion injury. Some researches found that ischemic postconditioning was one of the most powerful protective mechanism, which has become a new research focus. Reperfusion is a process which can be foreseen and controlled. Some scholar's studies have shown that "controlled reperfusion" could reduce myocardial infarction size, lessen myocardial edema and no reflow response, which promoted the concept of ischemic postconditioning.The Intracellular calcium antagonist Fasudil is a specific Rho-kinase inhibitor, which is metabolized to Fasudil hydrochloride in liver in vivo. Fasudil specifically suppresses Rho-kinase, its efficacy is 100 times higher than protein kinase C (PKC) and 1000 times higher than myosin light chain (MLC) kinase. After Fasudil was marketed in Japan in 1999, it has been used for treating cerebral ischemia, cerebral angiospasm, angina pectoris.
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