Study On The Paharmacological Mechanisms On Pannus Formation In RA In Treatment Of Complication Of Tongbiling

Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by inflammatory sinusitis, which has a substantial societal in term of cost, disability, and lost productivity. In the early period, the path physiology of rheumatoid is the inflamed symposium and panes formation, especial the formation of angiogenesis. Pannus has the similar function of the tissue of cancer, which has penetration. Pannus can penetrate and destroy the cartilage and bone which affect the diarthrodial joint and lead to disorder. It affects approximately 1 % of the population. They are no effective treatment in halting the progressive joint destruction, because the pathogeneses of rheumatoid arthritis remains incompletely understood. So the goal of the therapy is to relieve the pain,maintain the quality of life and preserve the economic productivity of the patient. Now the research of anti-rheumatic drugs has got the great progress, much insight to the cellular and molecular mechanisms involved. The ability of the new biological response to intervene in the disease process has generated enthusiasm for therapeutic interventions and for the possibility of future drugs that target individual inflammatory pathways. However, this excitement is tempered by the potential for long-term side-effects and toxicity.An inflamed synovium is central to the pathophysiology of rheumatoid arthritis. It is histologically striking, showing pronounced angiogenesis; cellular hyperplasia; an influx of inflammatory leucocytes, and changes in the expression of cell-surface adhesion molecules, proteinases, proteinases inhibitors, and many cytokines. Synovial changes in rheumatoid arthritis vary with disease progression. In the first weeks of the disease, tissue oedema and fibrin deposition are prominent and can manifest clinically as joint swelling and pain. Within a short period, the synovial lining becomes hyperplastic, and synovial-vessal endothelial cells transform into high endothelial venules early in the course of the disease. High endothelial venules are specialised post capillary venules found in secondary...