Feasible Study Of Cell Morphometric Analysis On Papillary Thyroid Carcinoma Diagnosis By FNA

Thyroid nodule is popular among population , the demand ofnodule thyroid diagnosis has increased very much in the last years. Most ofthyroid nodule is benign, the thyroid cancer however is a rare event.Differential diagnosis of thyroid nodule is very important to the patient withthyroid disease. Fine-needle aspiration biopsy (FNAB) of the thyroid glandhas been used in clinical practice, but false-positive and false-negativerates is high. The reliability of FNAB in differentiating benign from malignantfollicular lesions of the thyroid has been the subject of renewed debate recently.Improvement of FNAB is needed from the patient's and society's perspective.The aim of this study was to assess the utility of cell morphometric analysis bypreoperative FNA for detecting malignancy in patients with thyroid nodules;to assess variants of cell morhometric parameter between benign andmalignant cases;to assess variants of cell morhometric parameter in samecase between in nodule and out nodule. Surgically resected thyroid specimenincluding 35 papillary thyroid carcinoma (PTC),30 nodular goiter (ND) , 25follicular adenoma (FA)and 5 hyperfunctioning adenoma (HA) wasperformed by morphometric analysis with image system,7 parameter wasmeasured. Highly significant statistical difference was detected in everyparameter between benign and malignant cases.(p<0.05).73 patients withsingle thyroid nodule was studied, cells in nodule and out nodule wassmeared ,7 parameters was measured to assess variants of cell morhometricparameter in same case between in nodule and out nodule. we concluded asfollows: (1) 1.2 time bigger in nodule than out nodule in cell equivalentdiameter (CED) is of some value to differential diagnosis of benign andmalignant thyroid nodule.(2) 1.5 time bigger in nodule than out nodule innuclear area (NA) is of some value to differential diagnosis of benign andmalignant thyroid nodule.(3)1.3 time bigger in nodule than out nodule in thenuclear area to cytoplasmic area (N/C) is of some value to differentialdiagnosis of benign and malignant thyroid nodule.(4)1.5 time bigger outnodule than in nodule in nuclear regular form factor (NRFF) is of some valueto differential diagnosis of benign and malignant thyroid nodule.(5)pseudoinclusions in nuclear is of some value to differential diagnosis ofbenign and malignant thyroid nodule. Taking into consideration all 5 data canminimize false-negative rates. We analysed operated thyroid nodule in whichFNA under ultrasound scan had been performed, Puncture was carried out onnodule with features suggesting malignancy.2 cases with PTC was diagnosedon our cell morphometric analysis, this outcome is same with postoperativepathological diagnosis. Cell morphometric analysis on papillary thyroidcarcinoma diagnosis by FNA is feasible.We conclude that FNA is an effectivescreening test in the evaluation of the necessity for surgical treatment inpatients with thyroid nodules.