Molecular Cytogenetic Analysis Of Chromosome 13q Fragments And Corresponding Gene Status In Soft Tissue Tumors

Soft tissue rumors have various histological subtypes, with different morphological architectures and prognoses. They are challenging to pathologists due to their unusual character and the difficulties in predicting outcomes. Cytogenetic abnormalities and specific translocations are found in soft tissue tumors more commonly than in any other group of solid tumors. These abnormalities not only are useful in differentiating diagnoses but also providing insights into prognosis and pathobiology. Abnormality of chromosome 13q is found in many kinds of soft tissue tumors. The most common alterations are loss of 13q12-14, 13q21-22 or 13q34. Tumor suppressor gene Rb plays an important role in development and aggression of many kinds of tumors. Gene RFP2, KCNRG in 13q14 and gene KLF5 in 13q21 are also candidates for such a course. But few researches have been done with the status of chromosome 13q or the condition of the corresponding genes in various subtypes of soft tissue tumor.A particular subtype of soft tissue tumor, gastrointestinal stromal tumor (GIST), emerged as a distinct entity in recent years while rapid progress about its tumorigenesis and morphological variants has been achieved. Standard protocols have established for diagnose and treatment of GIST, but difficulties are still common in differentiating diagnoses and predicting biological behavior. Recently many studies have been carried out to reveal the biological and genetic underpinnings of GISTs. Constitutive activation of the KIT or PDGFRA receptor tyrosine kinase is considered as a central and early pathogenetic event in most GISTs and generally results from oncogenic mutations. Loss of 14q11.1-12, 14q23-24, 22q13.33 and 22q11.22 are also common and early event in oncogenesis of GISTs. Some researchers have found loss of 1p and 13q in GISTs and presumed they were most likely the chromosomal loci...