Studies Of The Effect Of N(4-hydroxycarbophenyl) Retinamide (RII) On The Biological Properties Of Human Nasopharyngeal Carcinoma Cell Lines And Associated Biomolecular Mechanisms.

The effect of N(4-hydroxycarbophenyl) retinamide (RII), a new synthetic analogue of retinol with low toxicity, on the biological properties of human nasopharyngeal carcinoma cell lines(HNC) and associated biomolecular mechanisms were studied. In addition, the endoplasmic reticulum system(ER) in whole-mount HNCs were also observed, using potassium permanganate as a fixti?e, The results were as following:1, RII(10 nmol. L) caused detectable morphologic differentiation of HNCs,2, RII resulted in growth inhibition of HNCs in vitro and decrease in the ability of these cells to penetrate Matrigel-coated filters using a reconstituted basement membrane invasion assay.3,The adhesion of HNC parent and its variants to different matrix, including plastic, fibronectin(FN), and...