A Preliminary Study On The Role And Mechanism Of Notch Signaling Pathway In Human Cervical Tumorigenesis

Human cervical cancer represent a major subset of female tumors throughout the world, especially in the developing countries. In recent years, its incidence and death rates have increased. Infection with high risk human papilloma virus (HPVs) is a majar risk factor for the development of the disease. However, the mechanisms underlying the disruption of this key factor in the tumorigenesis of human cervical carcinoma are still not fully elucidated.The Notch signaling cascade is remarkably conserved from Drosophila to man, and the complexity of this cascade is higher in mammals. Receptor-ligand interaction between two neighbouring cells leads to successive proteolytic cleavages of Notch, resulting in the release of the intracellular domain (ICN) of the receptor. ICN translocates to the nucleus where it converts the transcription factor CBF1/Su(H)/LAG1 (CSL) from a repressor to a transcriptional activator. Notch signaling is involved in a variety of cell differentiation, proliferation and...