The Preliminary Investigation Of A Mechanism By Which LPS Induces Periodontal Inflammatory And Bone Loss Through Human T Lymphocyte Cells Activation And Tumor Necrosis Factor-α

Periodontitis is an infectious disease caused by periodontopathic bacteria. There are reports to show that the variation of cytokines or T cells is involved in the progress of periodontal disease. Nowadays, many studies focused on the effect of T cells and their productions on periodontitis. The function of TNF and TNF receptors has been confirmed. Activated T cells produce cytokines relevant to osteoclastogenesis such as TNF-α, which induces bone loss when combined with osteoblasts. TNF signals through its two receptors. Soluble forms of TNF receptors (TNFR) are generated by proteolytic cleavage of the extracellular domain of TNFR. This soluble TNFR (sTNFR) can compete for TNF with the cell surface receptors and result in blocking the TNF-α activity in the infection and bone resorption.In this study, the effect of human T cells from periodontitis patients and normal people on periodontal tissues after repeated injections of endotoxin was investigated in vitro and in vivo, and the effect of human T lymphocyte cells on LPS induced bone resorption was discussed. The results as following:...