The Analgesia Study On Implanting APA Microcapsulated NIH3T3 Cells Transfecting RPENK Gene

Pain is an unpleasant sensory and emotional experience association with tissue or potential tissue damage, which provide the menace warning to the body. Many diseases and injury go with the pain and especially the chronic severe pain compromises his or her quality of life, and can become very stressful for the family and society. So it is one of the current subjects to search more effective new method in the pain research domain.The method of cell analgesia put forward by American researchers made a great breakthrough in the chronic pain therapy in the late of 1980s. The development and use of cellular minipumps bioengineered to secrete various anti-nociceptive molecules for the reversal of neuropathic pain. Nowadays, chromaffin cell is popular in cell transplantation. But there are some disadvantages such as the difficulty of cell original culture, immune rejection against the xenografted cells and the cell short survival. So many people focus on the transgenic analgesic to resolve this problem better.Gene engineering cell transplantation uses the cells to secrete anti-nociceptive substance through gene engineering technology. For the chronic pain gene therapy, the...