The Study On Frequent Influence Of Subclinical Epileptiform Discharges To Sleep Architecture And Cerebral Function

Background and Objectives:There is an extremely intimate relationship between sleep and epilepsy. In contrast to seizures, the relationship of interictal epileptiform discharges (IEDs) to sleep has not been well characterized. Sleep is a potent activator of epileptiform discharges. Worsening sleep can result not only in poor daytime function but also potentially in worsening seizure. Persistent daytime drowsiness in free-seizure patients is not always due to the side effects of some AEDs and may be independently linked with subclinical epileptiform discharges ( SEDs) . Greater understanding of the factors, such as sleep and SEDs, may provide insights into the pathophysiology and treatment of epilepsy.Benign childhood epilepsy with centrotemporal spikes (BECTS) is an idiopathic focal epileptic syndrome with a favorable long-term outcome. Its spike waves are infrequent during wakefulness, but may occur in runs of several discharges per page in sleep. Recent clinical data suggest that BECTS patients are more likely to show learning difficulties and behavioural disturbances than their peers. They are the excellent samples that explore the relationship of SEDs to sleep disruption and cognitive function.